DEL – Express: Hit Compounds Shipped in 20 Business Days
Summary
DEL – Express is our fastest route for teams with a purified target in hand – send us the protein, get hit compounds back in 20 business days.
How fast: Hit compounds shipped in 20 business days, from protein to physical compounds ready for confirmation.
What you provide: A biotinylated target of protein at microgram scale. That’s it.
What you get: A hit report and if you choose to: Purified off-DNA resynthesized hit compounds delivered to your bench.
What you keep: You own all foreground IP, data, and hits for the chemical series that you choose to nominate with no downstream financial obligations.
Service in brief
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1. You provide the biotinylated purified target protein (micrograms)
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2. We conduct the screening, perform the analysis and provide a report, including hit list with chemical structure information
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3. You order hits
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4. We synthesize the hits and ship to you
Timelines
Screening: 10 business days
Hit resynthesis: 10 business days (for up to 25 hits)
Keys
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Screen requires small quantities of purified biotinylated target protein (micrograms) -
Screen is conducted with 12 screening slots with varying conditions in parallel
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Screen is conducted in a homogeneous assay to avoid matrix binders and target denaturation
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Identifies hits and hit families
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Instant structure-activity relationship (SAR)
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High success rate (>75%)
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Low false positive rates (100% match between DNA code and compound)
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Applicable across disease areas and target classes (no structural information required)
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Straightforward and transparent data analysis
Business Model
- Simple fee-based plan with no reach-through and royalty payments
- Hit exclusivity and transparent cost structure – Client owns all hits and foreground IP without any downstream financial obligations
- The compensation plan comprises a total of 3 payments as a transparent cost structure
- Feasibility Study Fee – scales with work
- Screening Fee – scales with screening slots
- Chemical Series Nomination Fee
- The project flow is rapid and straightforward:
- Client provides the target protein (>100 µg)
- Vipergen performs the Feasibility Study (go-no-go)
- Vipergen performs one round of screenings with varying constructs and different libraries.
- Vipergen delivers a hit list and report, including metrics from screens and chemical structure information
- Hits are reserved for client for 1 year
- Client may resynthesize and test hits in relevant assays and use data for 1 year
- Vipergen can assist in off-DNA resynthesis as a fee-for-service
- Client may nominate Chemical Series for 1 year
- Vipergen assigns its rights to Nominated Chemical Series, and these become exclusive for you as a client
- Client own all foreground IP, data and hits of nominated series without royalty payment or other downstream financial obligations
DELs
Vipergen’s high fidelity DELs are synthesized using robust chemistry and with a purification steps after each chemical transformation, thus providing 100% correspondence between code and compound (no truncates).
Key drivers for library design
- Chemical diversity
- Physicochemical properties
- Fidelity
- Hit resynthesis (off DNA)
Target classes
- Kinases
- Oxidoreductase Proteases
- Hydrolases
- Isomerases
- Transferases
- Lyases
- Phosphatases
- Transcription factors
- Synthases
- E3 biquitin ligases
- Deubiquitinases (DUBs)
- Helicases
- Polymerases
- Nucleotide exchange factors
- Decarboxylases
- Ligases
- Integral membrane proteins
- G protein-coupled receptors (GPCRs)
- Ion channels
- Single-pass membrane proteins
- Nuclear receptors
- Cytosolic receptors
- Extracellular receptors
- Transcription factors
- E3 ligases
- Deubiquitinases (DUBs)
- Antibodies
- Cytokines
- Interleukins
- Growth factors
- Carrier proteins
- Adaptor proteins
- Oncoproteins
- Histone binders
- Methyl transferases
- Acetyltransferase
- Demethylases
- Deacetylases
- Viral proteins (enzymes and coat proteins)
- Bacterial proteins (enzymes and receptors)
- Fungal proteins (enzymes and receptors)
Technical information
Frequently Asked Questions
20 business days from receiving the biotinylated protein to receiving hits
Yes, clients own all chemical series which are nominated with no downstream financial obligations
A biotinylated target protein at microgram scale
No, the process is engineered for speed without raising the false-positive rate.
Use our DELs in Cells – Express instead