DELs in Cells – Snap: Fast, Affordable Hit Discovery
Summary
Snap is our fastest, most affordable route to real chemical starting points built for teams who want hits without a big campaign.
What you get: A screening report plus chemical structures for your top 20 hits, ready for confirmation
Who it is for: Startups and lean teams with tractable targets, or anyone who wants an early lead on a fixed, transparent budget. No purified protein is required as the screening runs in living cells.
What you keep: You own all nominated chemical series and foreground IP, with no royalties or downstream obligation.
Service in brief
- 1. You provide the amino acid sequence of the target protein(s)
- 2. We conduct an expression study
- 3. We conduct the screening, perform the analysis and provide a report, and chemical structure information for 20 top hits
Timelines
Expression study: 4 weeks
Screening: 4 weeks
Keys
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Screen is conducted in a living cell -
Screen is conducted using 2 screening slots (2 constructs or 2 DELs) in parallel
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Chemical structure information for 20 top hits
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More physiologically relevant conditions
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Lower attrition rate (assumed)
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Broader target space – no need for purified target protein
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High success rate (>70%)
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Shorter TAT
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Identifies hits and hit families
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Low false positive rates (100% match between DNA code and compound)
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Applicable across disease areas and target classes (no structural information required)
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Straightforward and transparent data analysis
Business Model
- Simple fee-based plan with no reach-through and royalty payments
- Hit exclusivity and transparent cost structure – Client owns all hits and foreground IP without any downstream financial obligations
- The compensation plan comprises one payment as a transparent cost structure covering everything
- The project flow is rapid and straightforward:
- Client provides the amino acid sequence for the target protein
- We express the protein and screen it with two slots e.g. varying which libraries are screened or which constructs are used
- Vipergen delivers a report including chemical structure information of top 20 hits
- Top 20 hits become exclusive for the client who owns all foreground IP without royalty payment or other downstream financial obligations
- Notes:
- A 90% refund is issued if we fail to express the target protein
- Positive and negative controls are provided by Vipergen
DELs
Vipergen’s high fidelity DELs are synthesized using robust chemistry and with a purification step after each chemical transformation, thus providing 100% correspondence between code and compound (no truncates).
Key drivers for library design
- Chemical diversity
- Physicochemical properties
- Fidelity
- Hit resynthesis (off DNA)
Target classes
Our streamlined DNA-encoded chemical library (DEL) screening service has successfully delivered hits and leads against numerous target classes. Including:
- Kinases
- Oxidoreductase Proteases
- Hydrolases
- Isomerases
- Transferases
- Lyases
- Phosphatases
- Transcription factors
- Synthases
- E3 biquitin ligases
- Deubiquitinases (DUBs)
- Helicases
- Polymerases
- Nucleotide exchange factors
- Decarboxylases
- Ligases
- Integral membrane proteins
- G protein-coupled receptors (GPCRs)
- Ion channels
- Single-pass membrane proteins
- Nuclear receptors
- Cytosolic receptors
- Extracellular receptors
- Transcription factors
- E3 ligases
- Deubiquitinases (DUBs)
- Antibodies
- Cytokines
- Interleukins
- Growth factors
- Carrier proteins
- Adaptor proteins
- Oncoproteins
- Histone binders
- Methyl transferases
- Acetyltransferase
- Demethylases
- Deacetylases
- Viral proteins (enzymes and coat proteins)
- Bacterial proteins (enzymes and receptors)
- Fungal proteins (enzymes and receptors)
Technical information
Frequently Asked Questions
The screening report and top 25 hits are delivered within 30 business days