Publications

Browse by topics

Core Technologies

Case Studies

Reviews & Perspectives

Designer Building Blocks

Core Technologies

The yoctoReactor, Binder Trap Enrichment and in-cell screening methods that our DNA-encoded libraries are built on.

2021

Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell

J. Am. Chem. Soc. 2021, 143, 7, 2751–2756

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2015

Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery

Curr. Opin. Chem. Biol. 2015, 26, 62–71

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2009

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

J. Am. Chem. Soc. 2009, 131, 1322-1327

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Case Studies

The platform applied to real targets, from p38 MAP kinase inhibitors to small molecule–RNA interactions.

2020

PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule–RNA Interactions

ACS Chem. Biol. 2020, 15 (9), 2374–2381

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2016

Novel p38 MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

Med. Chem. Commun. 2016, 7 (7), 1332–1339

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Reviews, Perspectives & Opinions

Overviews of DNA-encoded libraries and chemical libraries in drug discovery, written or co-written by our scientists.

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for their Synthesis

ChemistryEurope 2026, 4 (5), e70283

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Designer Building Blocks

Novel chiral heterocyclic and amino acid-like building blocks synthesized by our partner at KTU (Kaunas University of Technology), expanding the chemistry available to our libraries.

2026

Efficient 96-Well Plate Conjugation of Unnatural Amino Acid Building Blocks to DNA for DNA-Encoded Library Applications

Bioconjugate Chem. 2026, 37 (6), 1115–1120

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2026

Synthesis of 2,3-(Diheterocyclyl)Propanoic Acid Esters as New Building Blocks via Complementary Meldrum’s Acid and Aza- Michael Strategies

Molecules 2026, 31 (16), 2909

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2026

Facile Synthesis of Indole–, Pyrazole–, and Indazole–Pyrrolidine Hybrids as Novel Chiral Heterocyclic Building Blocks

Molecules 2026, 31 (15), 2736

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2026

Synthesis and Characterization of New Functionalized Pyrimidine (Hetero)Cyclic Molecular Hybrids as Chiral Heterocyclic Amino Acid Derivatives

Molecules 2026, 31 (15), 2689

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2024

Synthesis of chiral 2-(N-Boc-azetidin-3- yl)-2-alkylpropanoic acids as novel GABA derivatives

Monatsh. Chem. 2024, 155, 83–97

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2023

Synthesis and neuroprotective activity of 3‐aryl‐3‐azetidinyl acetic acid methyl ester derivatives. Archiv der Pharmazie 2023, 356: 2300378

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2023

Synthesis of New Azetidine and Oxetane Amino Acid Derivatives through Aza- Michael Addition of NH-Heterocycles with Methyl 2-(Azetidin- or Oxetan-3-Ylidene) Acetates

Molecules 2023, 28 (3), 1091

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2022

Regioselective synthesis of methyl 5-(N- Boc-cycloaminyl)-1,2-oxazole-4- carboxylates as new amino acid-like building blocks

Beilstein J. Org. Chem. 2022, 18, 102–109

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2021

Synthesis and Characterization of Novel Methyl (3)5-(N-Boc-piperidinyl)-1H- pyrazole-4-carboxylates

Molecules 2021, 26 (13), 3808

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2021

Methyl 2-Amino-4-[1-(tert- Butoxycarbonyl)azetidin-3-yl]-1,3- selenazole-5-carboxylate

Molbank 2021, M1207

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2020

Facile synthesis of novel amino acid-like building blocks by N-alkylation of heterocyclic carboxylates with N-Boc-3- iodoazetidine

Mol. Divers. 2020, 24, 1235–1251

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2018

L-Proline and related chiral heterocyclic amino acids as scaffolds for the synthesis of functionalized 2-amino-1,3-selenazole-5- carboxylates

Chem. Heterocycl. Compd. 2018, 54, 469–473

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Small molecule drug discovery for even hard-to-drug targets - identify inhibitors, binders and modulators	In living cell In vitro
Molecular Glue Direct	In living cell In vitro
PPI Inhibitor Direct	In living cell In vitro
Integral membrane proteins	In living cell In vitro
Selectivity Direct – multiplexed screening of target and anti-targets	In living cell In vitro
Express - optimized for fast turn-around-time	In living cell In vitro
Snap - easy, fast, and affordable	In living cell In vitro

Publications

Browse by topics

Core Technologies

Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell

Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

Case Studies

PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule–RNA Interactions

Novel p38 MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

Reviews, Perspectives & Opinions

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for their Synthesis

DNA-encoded chemical libraries

An overview of DNA-encoded libraries: A versatile tool for drug discovery

Streamlining hit discovery and optimization with a yoctoliter scale DNA reactor

Designer Building Blocks

Efficient 96-Well Plate Conjugation of Unnatural Amino Acid Building Blocks to DNA for DNA-Encoded Library Applications

Synthesis of 2,3-(Diheterocyclyl)Propanoic Acid Esters as New Building Blocks via Complementary Meldrum’s Acid and Aza- Michael Strategies

Facile Synthesis of Indole–, Pyrazole–, and Indazole–Pyrrolidine Hybrids as Novel Chiral Heterocyclic Building Blocks

Synthesis and Characterization of New Functionalized Pyrimidine (Hetero)Cyclic Molecular Hybrids as Chiral Heterocyclic Amino Acid Derivatives

Synthesis of chiral 2-(N-Boc-azetidin-3- yl)-2-alkylpropanoic acids as novel GABA derivatives

Synthesis and neuroprotective activity of 3‐aryl‐3‐azetidinyl acetic acid methyl ester derivatives. Archiv der Pharmazie 2023, 356: 2300378

Synthesis of New Azetidine and Oxetane Amino Acid Derivatives through Aza- Michael Addition of NH-Heterocycles with Methyl 2-(Azetidin- or Oxetan-3-Ylidene) Acetates

Regioselective synthesis of methyl 5-(N- Boc-cycloaminyl)-1,2-oxazole-4- carboxylates as new amino acid-like building blocks

Synthesis and Characterization of Novel Methyl (3)5-(N-Boc-piperidinyl)-1H- pyrazole-4-carboxylates

Methyl 2-Amino-4-[1-(tert- Butoxycarbonyl)azetidin-3-yl]-1,3- selenazole-5-carboxylate

Facile synthesis of novel amino acid-like building blocks by N-alkylation of heterocyclic carboxylates with N-Boc-3- iodoazetidine

L-Proline and related chiral heterocyclic amino acids as scaffolds for the synthesis of functionalized 2-amino-1,3-selenazole-5- carboxylates