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Snap – easy, fast, and affordable – Seamless small molecule drug discovery – Get an early lead

Snap – Our easy, fast, and affordable DNA-encoded chemical library (DEL) screening service for biotinylated proteins.

Service in brief

  • 1. You provide the biotinylated purified target protein (micrograms)
  • 2. We conduct the screening, perform the analysis and provide a report, and chemical structure information for 25 top hits

Timelines

4 weeks

Keys

  • Screen requires small quantities of purified biotinylated target protein (micrograms)
  • Screen is conducted using 4 screening slots (2 concentrations, 2 DELs) in parallel
  • Screen is conducted in a homogeneous assay to avoid matrix binders and target denaturation
  • Identifies hits and hit families
  • Chemical structure information for 25 top hits
  • High success rate (>75%)
  • Low false positive rates (100% match between DNA code and compound)
  • Applicable across disease areas and target classes (no structural information required)
  • High success rate (>75%)
  • Low false positive rates (100% match between DNA code and compound)
  • Applicable across disease areas and target classes
  • Straightforward and transparent data analysis

Business Model

  • Simple fee-based plan with no reach-through and royalty payments
  • Hit exclusivity for top 25 hits
  • The compensation plan comprises a total of 1 payment
  • The project flow is rapid and straightforward:
    • Client provides the biotinylated target protein (50 micrograms)
    • Vipergen performs the screening using 4 screening slots (2 concentrations, 2
      DELs) in parallel
    • Vipergen delivers a report, including metrics from screens and chemical
      structure information for top 25 hits
    • Vipergen assigns its rights to top 25 hits and these becomes exclusive for
      client
    • Vipergen permanently blocks top 25 hits from screening deck

DELs

Vipergen’s high fidelity DELs are synthesized using robust chemistry and with a purification
step after each chemical transformation, thus providing 100% correspondence between
code and compound (no truncates).

Key drivers for library design

  • Chemical diversity
  • Physicochemical properties
  • Fidelity
  • Hit resynthesis (off DNA)
Parameter Lib046 Lib056 Lib081
Size (million of compounds) 445 522 381
Chemistries
  • Acylation
  • Red. amination
  • SNAr
  • Acylation
  • Red. amination
  • Acylation
  • Red. amination
Compounds w 1 cyclic, tertiary amide 49% 47% 52%
Compounds w 2 cyclic, tertiary amides 42% 33%
Total number of building blocks (#) 1507 1327 1138
Designer building blocks (#) 979 755 617
Scaffolds (#) 368 343 295
Toxicophores (%) 1.1 0.4 1.1
Molecular weight (avg) 612 529 525
cLogP (avg) 2.8 0.75 0.9
HBA (avg) 8.7 6.3 6.2
HBD (avg) 2.8 2.8 2.9
Rotatable bonds (avg) 10.7 8.8 8.9
TPSA (avg) 153 139 137
Fsp3 (avg) 0.5 0.6 0.6

Target classes

Our streamlined DNA-encoded chemical library (DEL) screening service for purified proteins has successfully delivered hits and leads against numerous target classes. Including:
Enzymes
  • Kinases
  • Oxidoreductase Proteases
  • Hydrolases
  • Isomerases
  • Transferases
  • Lyases
  • Phosphatases
  • Transcription factors
  • Synthases
  • E3 biquitin ligases
  • Deubiquitinases (DUBs)
  • Helicases
  • Polymerases
  • Nucleotide exchange factors
  • Decarboxylases
  • Ligases
Membrane proteins
  • Integral membrane proteins
  • G protein-coupled receptors (GPCRs)
  • Ion channels
  • Single-pass membrane proteins
Receptors
  • Nuclear receptors
  • Cytosolic receptors
  • Extracellular receptors
Protein-protein interaction targets
  • Transcription factors
  • E3 ligases
  • Deubiquitinases (DUBs)
  • Antibodies
  • Cytokines
  • Interleukins
  • Growth factors
  • Carrier proteins
  • Adaptor proteins
  • Oncoproteins
Epigenetic targets
  • Histone binders
  • Methyl transferases
  • Acetyltransferase
  • Demethylases
  • Deacetylases
Pathogenic targets
  • Viral proteins (enzymes and coat proteins)
  • Bacterial proteins (enzymes and receptors)
  • Fungal proteins (enzymes and receptors)

Technical information

Do you have an inquiry?

Contact us today and explore partnership opportunities.

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Snap – easy, fast, and affordable