
Snap – easy, fast, and affordable – Seamless small molecule drug discovery – Get an early lead
Snap – Our easy, fast, and affordable DNA-encoded chemical library (DEL) screening
service for biotinylated proteins.
Service in brief
- 1. You provide the biotinylated purified target protein (micrograms)
- 2. We conduct the screening, perform the analysis and provide a report, and chemical structure information for 25 top hits
Timelines
4 weeks
Keys
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Screen requires small quantities of purified biotinylated target protein (micrograms)
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Screen is conducted using 4 screening slots (2 concentrations, 2 DELs) in parallel
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Screen is conducted in a homogeneous assay to avoid matrix binders and target denaturation
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Identifies hits and hit families
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Chemical structure information for 25 top hits
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High success rate (>75%)
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Low false positive rates (100% match between DNA code and compound)
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Applicable across disease areas and target classes (no structural information required)
-
High success rate (>75%)
-
Low false positive rates (100% match between DNA code and compound)
-
Applicable across disease areas and target classes
-
Straightforward and transparent data analysis
Business Model
- Simple fee-based plan with no reach-through and royalty payments
- Hit exclusivity for top 25 hits
- The compensation plan comprises a total of 1 payment
- The project flow is rapid and straightforward:
- Client provides the biotinylated target protein (50 micrograms)
- Vipergen performs the screening using 4 screening slots (2 concentrations, 2
DELs) in parallel - Vipergen delivers a report, including metrics from screens and chemical
structure information for top 25 hits - Vipergen assigns its rights to top 25 hits and these becomes exclusive for
client - Vipergen permanently blocks top 25 hits from screening deck
DELs
Vipergen’s high fidelity DELs are synthesized using robust chemistry and with a purification
step after each chemical transformation, thus providing 100% correspondence between
code and compound (no truncates).
Key drivers for library design
- Chemical diversity
- Physicochemical properties
- Fidelity
- Hit resynthesis (off DNA)
Parameter | Lib046 | Lib056 | Lib081 |
---|---|---|---|
Size (million of compounds) | 445 | 522 | 381 |
Chemistries |
|
|
|
Compounds w 1 cyclic, tertiary amide | 49% | 47% | 52% |
Compounds w 2 cyclic, tertiary amides | – | 42% | 33% |
Total number of building blocks (#) | 1507 | 1327 | 1138 |
Designer building blocks (#) | 979 | 755 | 617 |
Scaffolds (#) | 368 | 343 | 295 |
Toxicophores (%) | 1.1 | 0.4 | 1.1 |
Molecular weight (avg) | 612 | 529 | 525 |
cLogP (avg) | 2.8 | 0.75 | 0.9 |
HBA (avg) | 8.7 | 6.3 | 6.2 |
HBD (avg) | 2.8 | 2.8 | 2.9 |
Rotatable bonds (avg) | 10.7 | 8.8 | 8.9 |
TPSA (avg) | 153 | 139 | 137 |
Fsp3 (avg) | 0.5 | 0.6 | 0.6 |

Target classes
Our streamlined DNA-encoded chemical library (DEL) screening service for purified proteins has successfully delivered hits and leads against numerous target classes. Including:
Enzymes
- Kinases
- Oxidoreductase Proteases
- Hydrolases
- Isomerases
- Transferases
- Lyases
- Phosphatases
- Transcription factors
- Synthases
- E3 biquitin ligases
- Deubiquitinases (DUBs)
- Helicases
- Polymerases
- Nucleotide exchange factors
- Decarboxylases
- Ligases
Membrane proteins
- Integral membrane proteins
- G protein-coupled receptors (GPCRs)
- Ion channels
- Single-pass membrane proteins
Receptors
- Nuclear receptors
- Cytosolic receptors
- Extracellular receptors
Protein-protein interaction targets
- Transcription factors
- E3 ligases
- Deubiquitinases (DUBs)
- Antibodies
- Cytokines
- Interleukins
- Growth factors
- Carrier proteins
- Adaptor proteins
- Oncoproteins
Epigenetic targets
- Histone binders
- Methyl transferases
- Acetyltransferase
- Demethylases
- Deacetylases
Pathogenic targets
- Viral proteins (enzymes and coat proteins)
- Bacterial proteins (enzymes and receptors)
- Fungal proteins (enzymes and receptors)
Technical information
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Snap – easy, fast, and affordable |