Vipergen ApS
Gammel Kongevej 23A
1st floor
1610 Copenhagen
Denmark
VAT: DK28851758
Chemical building blocks (BBs) are brought into close proximity which facilitates chemical reaction and the attached DNA ultimately encodes the final product.
The overall design has favorable implications for the scope and reliability of the chemistry, the stability of the structure, and, ultimately, the capability for addressing the most challenging targets. 100% correspondence between code and synthesized compound is ensured by purification steps using the DNA as purification handle after each chemical step.
A fundamental difference between conventional HTS screening and DEL, is that hits identified by DEL screens need to be resynthesized off DNA. Therefore, we have a particular focus on a low false positive rate.
The chemical building blocks (BBs) are responsible for the vast majority of atoms and bonds in the library compounds. Consequently, BBs represent our primary focus for generating chemical diversity. We use commercial available BBs when possible, but are using in-house designed BBs in increasing numbers to satisfy the need for generating interesting and novel diversity.